Gyno Gurus Podcast
Alexandra MacLean, WHNP-BC, and Peter Mandel, MD, FACOG, are women’s health clinicians and co-hosts dedicated to translating medical evidence into clear, practical guidance. Their conversations help listeners understand their bodies, ask better questions, and make confident decisions—without the jargon.
Listen on:
Episodes
Oct 4, 2025
Oct 4, 2025
35 min
Today we’re breaking down insulin resistance — what it really means, why it happens, and how you can spot it early. We’ll walk through what’s actually going on in your body when your cells stop responding to insulin, how that leads to cravings, fatigue, and weight gain, and which tests can help you find out if you’re at risk.
💡 In this episode:
What insulin resistance actually is (in plain English)
The most common signs and symptoms
Which labs and tests are most accurate (fasting insulin, A1c, and more)
Why catching it early matters for your long-term health
Chapters:
00:00 Intro
02:00 Lets talk about Insulin, Glucagon, and Glucose
07:48 Simply Put, What is Insulin Resistance?
11:15 Why does Insulin Resistance Happen?
14:02 Signs & Symptoms
19:45 Impact of Sugar on the Brain
21:18 Testing - Fasting Glucose, Liver Function, OGTT, Insulin levels, A1C
31:17 Continuous Glucose Monitoring (CGM) Devices
32:57 Episode Summary
🎧 Listen Everywhere: Spotify | Apple Podcasts | Podbean | YouTube
📌 Hashtags: #InsulinResistance #MetabolicHealth #BloodSugar #DiabetesAwareness #HealthPodcast
Sep 20, 2025
Sep 20, 2025
30 min
Insulin Resistance: What it is, how to test it, and evidence-based ways to improve it. In this episode we break down insulin’s role in metabolism, the difference between normal vs optimal glucose/insulin ranges, the most useful labs (and how to read them), and practical strategies that can improve insulin sensitivity.
Your Hosts: Alexandra Marks, WHNP-BC
Peter Mandel, MD, FACOG
Follow us on Instagram:
https://www.instagram.com/GynoGurusPodcast/
https://www.instagram.com/DrPeterMandel/
Follow our channel on YouTube: The Gyno Gurus Podcast
Chapters:
00:00 Introduction
03:12 What is Insulin (Anatomy & Physiology)
06:23 Optimal vs Normal Glucose Levels
08:34 Testing Glucose & Insulin Levels
15:48 Consequences of Insulin Resistance
16:40 How Insulin affects Glucose
19:10 Prevalence & Causes of Insulin Resistance
21:35 Treatment Options
25:23 Is Insulin Resistance Reversible
26:46 Summary & Take Home Message
Disclaimer This video is for educational purposes only and is not medical advice. Talk to your healthcare professional before making changes to your meds, diet, or exercise—especially if you have diabetes, are pregnant, or take glucose-lowering medications.
#InsulinResistance #MetabolicHealth #Type2Diabetes #BloodSugar #Glucose